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Herstatin, Mouse Anti Human ( ERBB2 Antibody )
TypeMouse Anti Human Monoclonal.CloneP7H3BV.ImmunogenAnti-human ErbB2 mAb, is derived from mice immunized with the recombinant human ErbB2 (43.4 kDa, 397 a.a. and one extra N-terminal Methionin) purified from E. coli.Antigen Amino Acid
Data sheet
| Clone | P7H3BV. |
| Applications | ELISA, Western blotting. |
| Protein Background | HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2. |
| Synonyms | NEU, NGL, HER2, TKR1, HER-2, c-erb B2, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen. |
| Type | Mouse Anti Human Monoclonal. |
| Immunogen | Anti-human ErbB2 mAb, is derived from mice immunized with the recombinant human ErbB2 (43.4 kDa, 397 a.a. and one extra N-terminal Methionin) purified from E. coli. |
| Ig Subclass | IgG2b. |
| Protein formulation | The ERBB2 antibody is lyophilized in 0.05M phosphate buffer, 0.1M NaCl, pH 7.2. AZIDE FREE. |