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Interleukin 17E, Mouse Anti Human ( IL17E Antibody )
TypeMouse Anti Human Monoclonal.CloneYR-hIL17E.Immunogenr.Human IL-17EIg Subclassmouse IgG2a.Purification MethodProtein A.Protein formulation1mg/ml in PBS (after reconstitution).Shipping ConditionsAntibody is shipped lyophilized at ambient
Data sheet
| Clone | YR-hIL17E. |
| Applications | Direct ELISA, Immuneprecipitation, immunohistochemistry. |
| Protein Background | IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesnt induce allergic inflammation in vivo. |
| Synonyms | IL-25, IL-17E, IL17E, IL25, Interleukin-25. |
| Type | Mouse Anti Human Monoclonal. |
| Immunogen | r.Human IL-17E |
| Ig Subclass | mouse IgG2a. |
| Purification Method | Protein A. |
| Protein formulation | 1mg/ml in PBS (after reconstitution). |
| Storage Procedures | In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |