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Vimentin, Mouse Anti Human Antibody, FITC ( Vimentin Antibody, FITC )
TypeMouse Anti Human Monoclonal Antibody.ClonehVimentin.ImmunogenPurified Human Vimentin.Ig Subclassmouse IgG1.Purification MethodIon exchange column.Protein concentration1mg/ml in PBS (after reconstitution).Shipping ConditionsAntibody is shipped
Data sheet
| Clone | hVimentin. |
| Applications | Immunohistochemistry. |
| Protein Background | Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines. |
| Type | Mouse Anti Human Monoclonal Antibody. |
| Immunogen | Purified Human Vimentin. |
| Ig Subclass | mouse IgG1. |
| Purification Method | Ion exchange column. |
| Storage Procedures | In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |