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Polyclonal Anti-GCS/GCLC

FM-A10319

$320.00

Data sheet

Size 100ug/vial
Storage At -20C for one year. After reconstitution, at 4C for one month.
Form lyophilized
Ig type rabbit IgG
Immunogen/Antigen A synthetic peptide corresponding to a sequence at the N-terminal of
Reconstitution 0.2ml of distilled water will yield a concentration of 500μg/ml.

More info

Background
GCLC, Glutamate--cysteine ligase catalytic subunit, is an enzyme that in humans is encoded by the GCLC gene.Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6p12.1. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.

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