| Specificity |
reactive with Human/Mouse/Rat Total SHP-2, reactivity with other related proteins not observed |
| Assay Range |
140-9000pg/ml |
| Sensitivity |
13.5 pg/ml |
| Size |
96 Tests |
| Storage |
2-8℃ |
| Background |
Human/Mouse/Rat Total SHP-2 also known as protein-tyrosine phosphatase 1D (PTP-1D) or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. |
| Sample type |
serum, plasma, cell culture supernatant |
| Assay duration |
4 hours |
| Assay format |
Sandwich |
| Alternative Name of Analyte |
PTPN11；BPTP3；CFC；NS1；PTP-1D；PTP2C；SH-PTP2；SH-PTP3；SHP2 |
