Data sheet
| Specificity | reactive with Human Total Tie-1, reactivity with other related proteins not observed |
| Assay Range | 422-27000pg/ml |
| Sensitivity | 40.5 pg/ml |
| Size | 96 Tests |
| Storage | 2-8℃ |
| Background | Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells. |
| Sample type | serum, plasma, cell culture supernatant |
| Assay duration | 4 hours |
| Assay format | Sandwich |
| Alternative Name of Analyte | TIE；tie-1；D430008P04Rik |
More info
TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells. TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.