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Human Amyloid Beta Peptide 1-42 A Beta1-42 ELISA Kit
BG-HUM10309
Human Amyloid Beta Peptide 1-42 ELISA KitFor research use only. Not for use in diagnostic procedures.For general protocol and instruction, please click the following links:Quantitative Elisa Kit InstructionSandwich ELISA kit general instruction
Data sheet
| Background | Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold. Aβ is the main component of amyloid plaques (extracellular deposits found in the brains of patients with Alzheimer's disease).Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis (a muscle disease), while Aβ can also form the aggregates that coat cerebral blood vessels in cerebral amyloid angiopathy. The plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as the prions associated with protein misfolding diseases. |
| Assay Type | Sandwich ELISA |
| Kit Type | Colorimetric |
| Assay Time | 4.5 hours |
| Sample Type | Tissue extract, CSF, Serum, Plasma, Cell culture medium |
| Assay Range | 7.8 pg/ml - 500 pg/ml |
| Sensitivity | 2.3 pg/ml |
| Specificity | recognizes both native and recombinant amyloid beta peptide (1-42), but not (1-40) |
| Gene ID | 351 |
| UniProt ID | P05067 |
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Human Amyloid Beta Peptide 1-42 ELISA Kit
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Different lot may vary, please follow the instruction coming with the kit.