Assay Range | 0 - 100 ng/ml |
Leptin is a secreted hormone made by fat cells, which regulates the amount of fat stored in the body. It may function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. Leptin does this by adjusting both the sensation of hunger, and adjusting energy expenditures. Although regulation of fat stores is deemed to be the primary function of leptin, it also plays a role in other physiological processes, as evidenced by its multiple sites of synthesis other than fat cells, and the multiple cell types beside hypothalamic cells which have leptin receptors.