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Hyaluronidase ( HYAL1 )
DescriptionHyaluronidase is an enzyme that temporarily and reversibly breaks down the polysaccharide, hyaluronic acid, which is found between the cells of connective tissue. Hyaluronic acid may be thought of as the "glue" that holds cells together.
Data sheet
| Formulation | The enzyme was lyophilized 1xPBS and 2% mannitol. |
| Solubility | It is recommended to reconstitute the lyophilized Hyaluronidase in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. |
| Description | Hyaluronidase is an enzyme that temporarily and reversibly breaks down the polysaccharide, hyaluronic acid, which is found between the cells of connective tissue. Hyaluronic acid may be thought of as the "glue" that holds cells together. Hyaluronic acid is a mucopolysaccharide that exists in the human tissue matrix. It can constrain the diffusion of the extracellular fluid. Hyaluronidase makes the glucoseamine of the hyaluronic acid molecules hydrolyzed and depolymerized, thus decreases the viscosity of the body fluids and increases the flow and diffusion of the intercellular fluids. In this way the physic liquor, exudates or blood in local areas can be more easily diffused, and the drug can be more easily absorbed. Thus the local tissue tension and pains can be relieved. And it will also be easier for the edema and inflammatory exudates to be absorbed and dissolved. This product is a basic component of the articular cartilage. It can nourish, protect and maintain the functions of the joints. |
| Expression host | Bovine Testis. |
| Synonyms | Hyaluronidase-1, EC 3.2.1.35, Hyal-1, Hyaluronoglucosaminidase-1, LUCA-1. |
| Stability | Lyophilized Hyaluronidase although although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Hyaluronidase should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Physical Appearence | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Activity | 300 IU/mg. |