| Specificity |
reactive with Human/Mouse Total Pin1, reactivity with other related proteins not observed |
| Assay Range |
422-27000pg/ml |
| Sensitivity |
40.5 pg/ml |
| Size |
96 Tests |
| Storage |
2-8℃ |
| Background |
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene.(Not to be confused with PIN1 (Pin-formed 1), an auxin transporter in Arabidopsis thaliana.)Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine-Proline motifs. The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function. Studies have shown that the deregulation of Pin1 may play a pivotal role in various diseases. Notably, the up-regulation of Pin1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of Pin1 may have therapeutic implications for cancer and immune disorders. |
| Sample type |
serum, plasma, cell culture supernatant |
| Assay duration |
4 hours |
| Assay format |
Sandwich |
| Alternative Name of Analyte |
PIN1；DOD；UBL5 |
